Abstract: Rational selecting the design ground motion parameters is the basic work of aseismic design for engineering construction. Taking the engineering construction of Nantong City as an example, this paper analyzes the main problems in the selection of design ground motion parameters. The main basis for selecting design ground motion parameters in this area is “China Ground Motion Parameter Zoning Map”（GB19306—2015）and related industry standard for seismic design of engineering construction. For important projects or projects with serious secondary disasters after earthquake damage, special seismic safety evaluation should be carried out to determine the design ground motion parameters. On the premise of the same maximum acceleration, the most powerful seismic wave affecting Nantong city comes from the destructive earthquake of M6 on the Binhai fault and Bengchahe fault in Northern Jiangsu Province. For the frequent earthquake waves in Nantong City, it is suggested to select the acceleration records of the earthquakes with the epicenter distance of about 60 km from M6, which can be used for the seismic design of the structure after adjusting the seismic acceleration to 35 cm/s².